STAT3 and neoplasm: The anti-tumorigenic mechanisms attributed to ApoA1 are related to the modulation of the tumor microenvironment, the inhibition of tumor neoangiogenesis, the regulation of inflammatory signaling [e.g., through the signal transducer and activator of transcription 3 (STAT3) pathway] and to decreased levels of pro-invasion factors, such as matrix metalloproteinase-9 (MMP-9) (Zamanian-Daryoush et al., 2013; Gkouskou et al., 2016; Jia et al., 2017).