Importantly, subcutaneous injection of human ApoA1 decreased tumor burden, prevented metastatic growth and improved survival of mice previously inoculated with melanoma cells, after the establishment of palpable tumors and metastasis (Zamanian-Daryoush et al., 2013), arguing for the potential therapeutic applications of ApoA1 for cancer at more advanced stages. The gene discussed is APOA1; the disease is cancer.