Half of all melanoma patients carry activating mutations in proto-oncogene v-Raf murine sarcoma viral oncogene homolog B (BRAF) that cause constitutive mitogen-activated protein kinase (MAPK) signaling and subsequently, unrestricted melanoma growth (Kumar et al., 2004; Wellbrock and Hurlstone, 2010). Here, BRAF is linked to melanoma.