Moreover, the deficiency in exocytosis, endocytosis, and vesicles recycling may underlie a common pathogenic pathway shared by other PD risky genes (i.e., synaptotagmin-11, parkin, LRRK2, DJ-1, synaptojanin1, and TMEM230) (Abeliovich and Gitler, 2016; Pan et al., 2018; Wang et al., 2018). This evidence concerns the gene PRKN and Parkinson disease.