In summary, the current study reveals a novel role of EBV infection in promoting migratory and invasive ability of NPC cells involving perturbed glucose metabolic pathways and nuclear translocation of PDHE1α mediated by LMP1/IGF1/mTORC2 signaling axis and may reveal new and potentially effective therapeutic target in clinical management of NPC. Here, IGF1 is linked to nasopharyngeal carcinoma.