Moreover, cell viability and colony formation assays revealed that IGFBP5 silencing abrogated the tumor suppressive effect of PKNOX2 in AGS cells overexpressing PKNOX2 (Fig. 6g), suggesting that tumor suppressive function of PKNOX2 in GC cells was dependent on IGFBP5. The gene discussed is PKNOX2; the disease is neoplasm.