Next, we detected the expression of several apoptosis markers and found that PKNOX2 induced cleavage of caspase-8, caspase-9, caspase-7, caspase-3, and poly(ADP-ribose) polymerase (PARP), suggesting that PKNOX2 promoted apoptosis in GC cells. The gene discussed is CASP8; the disease is gastric cancer.