The generation of a Disc1 svΔ2 rat model was chiefly motivated by our understanding of DISC1 as a major molecular scaffold protein interacting with GSK3β, NDEL1, LIS1, PDE4, KAL7, TNIK, and others in multiple neuronal processes, thus placing it at the molecular intersection of schizophrenia and numerous other major psychiatric illnesses44,45. The gene discussed is DISC1; the disease is schizophrenia.