The generation of a Disc1 svΔ2 rat model was chiefly motivated by our understanding of DISC1 as a major molecular scaffold protein interacting with GSK3β, NDEL1, LIS1, PDE4, KAL7, TNIK, and others in multiple neuronal processes, thus placing it at the molecular intersection of schizophrenia and numerous other major psychiatric illnesses44,45. This evidence concerns the gene PDE4A and schizophrenia.