CRP and obesity due to melanocortin 4 receptor deficiency: A systematic review and a reciprocal Mendelian randomization study suggested that obesity was correlated with elevated levels of CRP.41,42 Moreover, increasing evidence points to the negative association between physical activity and inflammatory biomarker levels.43,44 Given the health benefits in metabolic regulation from physical activity, we propose that, besides diet, weight control, smoking cessation, and increasing physical activity may contribute to lower CRP levels.