GJA5 and heart failure: Taken together, these findings indicate that cardiac hypertrophy of Cx40−/− and Cx40−/−Panx1−/− mice may lead to myocardial remodeling; however, hearts from Cx40−/− and Cx40−/−Panx1−/− mice do not yet possess augmented extracellular matrix protein depositions or alterations in ICD integrity that would lead to heart failure.