Cardiac hypertrophy is frequently associated with hypertension, and has been previously reported in the Cx40−/− mouse, thus arterial blood pressure was assessed in WT, Cx40−/−, Panx1−/−, and Cx40−/−Panx1−/− mice via carotid pressure transducer catheterization. This evidence concerns the gene PANX1 and cardiac hypertrophy.