PDPN and cancer: Podoplanin signalling through ROCK (herein referring to both ROCK1 and ROCK2) has been reported to enhance the ability of cancer-associated fibroblasts (CAFs) to invade collagen matrices in vitro (Neri et al., 2015) and fibroblast-like cell lines to migrate across Transwell filters (Suchanski et al., 2017).