Moreover, expression of podoplanin can be modified by MSC responses to inflammatory mediators (Sheriff et al., 2018; Croft et al., 2016), and is often upregulated in inflamed tissues (Del Rey et al., 2014; Inoue et al., 2015; Croft et al., 2016; Hitchcock et al., 2015) and cancer (Schacht et al., 2005), where it could contribute to further pathology. The gene discussed is PDPN; the disease is cancer.