In an acute model, Lee et al. [29] stimulated microglia by injecting the endotoxin lipopolysaccharide (LPS) into the hippocampus of 4.5-month-old rTg4510 mice, a tauopathy model, and observed significant increases in pre-tangle phospho-tau 1 week after administration. This evidence concerns the gene MAPT and tauopathy.