In line with the dramatic redistribution of Aqp4 in 4 h pMCAO animals, we consistently observed decreased levels of Aqp4 in ischemia-affected areas, reaching statistical significance in the cortex (p = 0.018), whereas the differences failed to reach statistical significance in the ischemia-affected striatum (Fig. 7b, p = 0.2; n = 6). Here, AQP4 is linked to ischemia.