MiRNA-219-2 and miRNA-199b were found to map centromeric to the abl1 gene within the chromosomal region at 9q34 that was frequently lost in CML patients with der(9) deletions, induced downexpression of miRNA-199b and miRNA-219-2, which resulted in the resistance of CML to imatinib [117, 119]. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.