CARD11 and infection: The largest gene ontology cluster enriched in the pathway analysis was regulation of T cell differentiation, a hallmark of innate immune system development, which includes genes such as tripartite motif containing 22 (TRIM22, interferon signaling [50]), interleukin 1 receptor-associated kinase 2 (IRAK2, inflammatory response to infection [51]), and caspase recruitment domain family member 11 (CARD11, critical component of T cell and B cell signaling [52]).