SNHG20 is up-regulated in osteosarcoma tissues and cells and knockdown of SNHG20 up-regulates the expression of apoptosis-related protein Bax, decreases the expression of Bcl-2, inhibits the activity of caspase-3 and caspase-9, and promotes the apoptosis of osteosarcoma cells [43]. Here, CASP3 is linked to osteosarcoma.