ELAV like RNA binding protein 1 (ELAVL1, HuR) is highly expressed in osteosarcoma, and by binding to high mobility group AT-hook 1 (HMGA1) 3’UTR increases the stability and expression of HMGA1 mRNA, promoting the progression of osteosarcoma [30]; HuR also binds and increases the expression of lncRNA SRY (sex determining region Y)-box 5 (Sox5) and promotes the migration and invasion of human tongue squamous cell carcinoma [31]. Here, SOX5 is linked to osteosarcoma.