However, the expression level of FOXK1 in breast cancer is significantly lower than that in adjacent lung cancer tissues; FOXK1 knockdown decreases the expression of E-cadherin and increases the expression of N-cadherin, which suggests that FOXK1 inhibits the invasion of breast cancer cells by inhibiting epithelial-mesenchymal transition (EMT) [21]. The gene discussed is CDH2; the disease is lung carcinoma.