TUBA1A and Global developmental delay: The missense variant c.518C > T, p.(Pro173Leu) identified in individual i084n and the missense variant c.641G > A, p.(Arg214His) in individual i086n, located in exon 4 of TUBA1A, were both previously reported either in an affected individual with autism spectrum disorder [39] (c.518C > T, p.(Pro173Leu)) or in several affected individuals with developmental delay and complex cerebral malformations [20, 40] (c.641G > A, p.(Arg214His)).