The administration of AdCMV-miR-193a increased miR-193a levels in lung tissue, decreased p-mTOR levels, increased p-Akt, Beclin1 and LC3 levels (Fig. 2m-r), increased autophagy levels in PQ-induced lung tissue, decreased profibrotic proteins TGF-β1, α-SMA and Collagen I and genes TGF-β1 and Collagen I mRNA levels(Fig. 2h-l), and reduced PQ-induced pulmonary fibrosis (Fig. 2a-b, d-e). This evidence concerns the gene AKT1 and pulmonary fibrosis.