AKT1 and neoplasm: There was very low or no expression of ki67 protein (Fig. 10f) in residual tumor as compared to high expression of TFF3 in residual tumor cells (Fig. 10a) suggesting that residual tumor cells have a low proliferating activity, this is supported by the high expression of Bcl2 (Fig. 10b) and p-AKT-1 (Fig. 10c) by residual tumor cells.