EGF has been reported to induce focal adhesion disassembly and enhance tumour cell motility through EGFR-activated E-cadherin endocytosis [30,31], and SGSM2 has been reported to interact with RAB family proteins, who function in recycling of vacuoles between the early endosome and plasma membrane [16]. This evidence concerns the gene AGFG1 and neoplasm.