Among the 11 germline-mutated cancer-related genes, two (ACACA and DEPTOR) are known to be associated with common driver genes: ACACA is associated with BRCA1, and DEPTOR with EGFR. One particular missense variant in the ACACA gene (c.C1948T, p.Arg650Trp (NM_198837.1, exon 16)) has been predicted as deleterious, leading to a loss of function of Acetyl-CoA carboxylase alpha which is a crucial enzyme for long-chain fatty acid synthesis [32]. This evidence concerns the gene DEPTOR and cancer.