The clinical characteristics taken into account are: age, sex, BMI, focus of infection, history of CAD, HTN, DM, stroke, CKD, cancer cirrhosis, IL-6, caloric meet on day 1 and day 3, and HLA-DR expression on day 3 and day 7; the amount of protein intake was not significantly associated with 28-day mortality. The gene discussed is IL6; the disease is infection.