IFIH1 and Aicardi-Goutieres syndrome: AGS involves mutations in RNases (RNASEH2A, RNASEH2B, RNASEH2C), a DNase (TREX1), double-stranded RNA (dsRNA) editing (ADAR), dsRNA recognition and binding (IFIH1), and activation of the innate immune system (SAMHD1, IFIH1) [30].