For example, the OAK study that tested Atezolizumab in patients with advanced or metastatic NSCLC previously treated by chemotherapy used a composite score evaluating the expression of PD-L1 by tumor cells and tumor microenvironment immune cells, whereas the clinical trials evaluating the efficacy of Nivolumab or Pembrolizumab in the same indication evaluated the expression of PD-L1 only in tumor cells. This evidence concerns the gene CD274 and neoplasm.