Furthermore, the H3K27ac epigenetic mark (associated to enhancers) was found in nine loci of the rest of the lncRNAs and their adjacent coding genes, which, in addition to the finding of a unique expression signature of these coding genes in ETV6/RUNX1 pre-B ALL, suggests a cis interaction between the lncRNAs and their neighboring coding genes [47]. Here, ETV6 is linked to acute lymphoblastic leukemia.