PANK2 and neurodegeneration with brain iron accumulation: Mutations in genes coding for the first (PANK2) and the last (COASY) enzyme of the biosynthetic pathway that produces Coenzyme-A (CoA) cause NBIA subtypes known as pantothenate kinase-associated neurodegeneration (PKAN) and CoA synthase protein-associated neurodegeneration (CoPAN), respectively.