In thyroid cancer, PATZ1 expression has been investigated in human thyroid cancer specimens and found to be downregulated with respect to normal thyroid tissue and increasingly downregulated going from well differentiated papillary carcinomas to poorly differentiated and anaplastic carcinomas, which suggests a tumor suppressor role involved in counteracting thyroid cancer progression toward a less differentiated phenotype [16,17]. The gene discussed is PATZ1; the disease is neoplasm.