We now report (i) an inverse relationship between FoxM1 and RASSF1A expression in CRC, (ii) inhibition of FoxM1 expression in mCRC cells resulting in increased RASSF1A expression, (iii) down-regulation of FoxM1 coinciding with increased phosphorylation of YAP, and (iv) downregulation of RASSF1A and increased FoxM1 overexpression. The gene discussed is RASSF1; the disease is colorectal carcinoma.