Similarly, the use of the ATR1 antagonist losartan has been found to reduce status-epilepticus-induced oxidative stress in the rostral ventrolateral medulla, which impacted the improvement of baroreflex-mediated sympathetic vasomotor tonus in experimental temporal lobe status epilepticus through the inhibition of superoxide anion generation from the p47phox subunit of nicotinamide adenine dinucleotide phophate oxidase, nitric oxide synthase II. The gene discussed is AGTR1; the disease is status epilepticus.