APLNR and epilepsy: There have been some positive findings for other neuropeptides, including apelin, as an endogenous ligand of angiotensin receptor-like 1 (APJ) in the PTZ-induced epilepsy model, and the reduction of APJ with apelin-13 in the PTZ group has indicated anticonvulsive (seizure-inhibition threshold, tonic–clonic latency) and neuroprotective properties that further enhance the role of angiotensinogen pathway targeting in epileptogenesis [88].