The activation of the MasR axis with diminazen aceturate has been found to have a beneficial role in the cognitive process of neurological diseases, such as Alzheimer’s, which might be related to the improvement of neuroplasticity and cognitive function in patients with epilepsy through the activation of the PI3K/Akt pathway, AMPc, a brain-derived neurotrophic factor, nicotinic and glutaminergic receptors, and the inhibition of tau and glycogen synthase protein contents, NF-kB and TNF-alpha [131]. This evidence concerns the gene TNF and epilepsy.