Due to this, the increased levels of Ang II and ATR1 in the microglia in the lithium-pilocarpine-induced epilepsy model were inhibited with ARBs, including losartan, which resulted in a reduction in microglia-mediated inflammation, epileptic cognitive impairment, neural loss and other neuroprotective effects, suggesting an interesting approach in the prevention of epilepsy and its comorbidities, including cognitive function [100]. This evidence concerns the gene AGTR1 and epilepsy.