Moreover, autophagy plays an important role in the degradation of different proteins correlated with degenerative diseases, such as mutated α-synuclein in Parkinson’s disease, mutant huntingtin in Huntington’s disease, and the mutant TAR DNA-binding protein 43 (TPD-43) in amyotrophic lateral sclerosis. The gene discussed is HTT; the disease is juvenile Huntington disease.