The tyrosine kinase family includes other members, including human epidermal growth factor receptor 2 (HER2/neu), vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and fibroblast growth factor receptor (FGFR2), which can be altered by activating critical pathways in tumorigenesis, cancer progression, survival, resistance to chemotherapy, and metastasis [31]. This evidence concerns the gene ERBB2 and cancer.