In the case of AD, two types of protein aggregate appear: soluble intracellular (monomer to oligomers) aggregates and insoluble extracellular (proto-fibril to fibrils) aggregates, which are mainly formed by beta amyloid (Aβ) [22], and other intracellular aggregates called neurofibrillary tangles (NFT) formed by hyperphosphorylated tau protein (tau) [23]. The gene discussed is MAPT; the disease is Alzheimer disease.