AKT1 and cancer: The specific molecular targets for curcumin that are therapeutically important in cancer-signaling pathways include cyclin-dependent kinases (CDKs), p53, Ras, phosphoinositide 3-kinase (PI3K), Protein kinase B (Akt), Wnt/β-catenin, and mammalian target of rapamycin (mTOR) [29].