Our results are in keeping with previous studies showing that the CpG islands of miR-205-5p are hypermethylated in metastatic cancers.43, 44 IR enhanced hypermethylation of miR-205-5p through Src phosphorylation, leading to decreased miR-205-5p expression and, consequently, increased levels of Bcl-w that promoted malignant activity and metastasis. The gene discussed is SRC; the disease is metastatic malignant neoplasm.