Knockdown of Bcl-w using small hairpin RNA (shRNA) in H460 and MDA-MB-231 cells suppressed IR-induced expression of the mesenchymal marker proteins (Figure 2A) and exhibited a decrease in the IR-induced migratory potential and invasive properties (Figure 2B) through downregulation of the mRNA levels of the matrix metalloproteinases (MMPs) MMP-2 and MMP-9, which were associated with tumor invasiveness (Figure 2C).34 The gene discussed is MMP9; the disease is neoplasm.