Lastly, the conventional PKC inhibitor Bisindolylmaleimide-I (GF109203X, Gö6850) has been used to treat the impairment of neurovascular coupling in type I diabetes mellitus in rats [143] as well as dilated cardiomyopathy and heart-failure in MLP knockout mice [42]. Here, PRRT2 is linked to type 1 diabetes mellitus.