CSRP3 and dilated cardiomyopathy: Our analysis of PLN phosphorylation in muscle lim protein (MLP) knockout mice, a model for dilated cardiomyopathy with known pathological involvement of PKCα, does show increased phosphorylation levels of monomeric PLN at Ser10 (Fig. 3B; monomeric PLN, as opposed to its pentameric version is thought to modulate SERCA activity).