Promising markers include neutrophil gelatinase-associated lipocalin (NGAL),N-Acetyl-β-D-Glucosaminidase (NAG), kidney injury molecule-1 (KIM-1),α1- and β2-microglobulin, liver-type fatty acid binding protein(L-FABP), and retinol binding protein (RBP4).3Some of these markers may be detected when the UAE increases and the GFRdecreases.5 MicroRNAs have been regardedas promising markers for the early diagnosis and monitoring of DKD.6 This evidence concerns the gene HAVCR1 and diabetic kidney disease.