Since the leader(L) protein of Theiler’s murine encephalomyelitis virus (TMEV), a member of theCardiovirus genus of Picornaviridae, is knownto disrupt nucleocytoplasmic transport [12, 13], we wondered whether TDP-43 proteinopathyoccurs in infections with this pathogen; however, it is known that different RNAbinding proteins and different protein compositions of the nuclear pore complex arepresent in different cell types [14]. The gene discussed is TARDBP; the disease is infection.