TARDBP and amyotrophic lateral sclerosis: We sought to investigate whether TDP-43 is mislocalized in infectionswith the acute neuronal GDVII strain and the persistent demyelinating DA strainof Theiler’s virus murine encephalomyelitis virus (TMEV), a member of theCardiovirus genus of Picornaviridaebecause: i) L protein of both strains is known to disrupt nucleocytoplasmictransport, including transport of polypyrimidine tract binding protein, anRNA-binding protein, ii) motor neurons and oligodendrocytes are targeted in bothTMEV infection and ALS.