For this reason, we investigated thelocalization in cells of i) fused in sarcoma (FUS), which like TDP-43 is a causeof familial ALS when mutated, and ii) polypyrimidine tract binding protein(PTB), which is known to be mislocalized in TMEV infections, where it plays arole in TMEV translation [18, 19]. The gene discussed is TARDBP; the disease is infection.