For all these reasons we sought to combine the MSC affinity for PDAC stroma, their capacity to deliver TRAIL variants and the reported sensitivity of PDAC to rhTRAIL to propose an approach where human MSC are armed by a soluble TRAIL (sTRAIL) and challenged in preclinical models providing evidences of safety and efficacy against a still deathly tumor. This evidence concerns the gene TNFSF10 and neoplasm.