In the past, others generated soluble TRAIL variants produced by E. coli, P.pastoris, the 293T cell line, by intra-tumor delivered adenoviral vector, by delivering of sTRAIL gene via nanoparticles targeting tumor stroma, by engineered (adeno- or lenti-viral vectors) human, rat and murine bone marrow MSC and by transfected mesenchymal cells derived from pancreatic tissue31,32,42–51. The gene discussed is TNFSF10; the disease is neoplasm.