Consistently, in our study, KPNB1 shRNAs (shKPNB1–1, 2) or specific inhibitor importazole (IPZ) potentiated TRAIL cytotoxicity in A172, U87, U118, U251 human glioblastoma cells but not in human fetal astrocytes (HA) (Fig. 1a–c). The gene discussed is TNFSF10; the disease is glioblastoma.