Mechanically, transforming growth factor β1 (TGF-β1) secreted by MSCs activated SMAD2/3 through TGF-β receptors, which then induced lncRNA MACC1-AS1 expression in GC cells and promoted FAO-dependent stemness and chemoresistance through antagonizing miR-145-5p. The gene discussed is TGFB1; the disease is gastric cancer.