MYCN and neuroblastoma: PRMT1-KD SK-N-SH cells proliferate slowly, an observation that is similar to that of the MYCN-overexpressed neuroblastoma cells with PRMT1 knockdown35. We also observed cellular senescence in the PRMT1-KD SK-N-SH cells (Fig. 2) that was previously not reported in neuroblastoma cells. The downregulation of PRMT1 results in reduced cell growth and cell cycle arrest in a spectrum of cancer cell lines30,31,44–46.