While reducing apoptosis in the intestine, the rescue through haplosufficiency of TRADD did not lead to lymphadenopathy and splenomegaly in the resulting Ripk1−/−Ripk3−/−Tradd+/− mice (Supplementary Fig. 4), unlike the severe lpr-like symptom in Ripk3−/−Fadd−/− or Ripk1−/−Ripk3−/−Fadd−/− mice (Supplementary Fig. 4)29,33. This evidence concerns the gene RIPK1 and Splenomegaly.