Proteomic and functional analyses revealed that CALCB, but not CALCA, is secreted by EwS cells and that suppression of either CALCB or its receptor’s component RAMP1 significantly reduced proliferation and clonogenic/spheroidal growth of EwS cells in vitro, as well as tumor growth in vivo, which can be mimicked in vitro by application of the small molecule CGRP receptor inhibitors MK-3207 and BIBN-4096 (Olcegepant). This evidence concerns the gene RAMP1 and neoplasm.