BDNF expression and secretion have also been observed in invasive front of primary tumors in GC patients and is strongly correlated with E-Cadherin downregulation and consequently with anoikis resistance (apoptotic cell death resulting from loss or inappropriate cell-matrix interactions24), invasiveness (higher cell proliferation and migration), disease progression, and poor prognosis25,26. This evidence concerns the gene BDNF and gastric cancer.