It is expressed ubiquitously in cells and plays a very important role in the intracellular (endocytosis, sorting) and extracellular (exocytosis, secretion) trafficking of proteins (e.g., receptors, ligands) and also in cell signaling events such as heterodimerization with Trk receptors (e.g., TrkB to enhance the pro-survival effects of BDNF in CRC). Here, BDNF is linked to colorectal carcinoma.