Alongside other tactics employed by tumor cells, such as elevated expression of PD-L1, which promotes further suppression of antitumor Teff responses through inhibitory interactions with PD-1 expressed by activated Teffs (60), tumor-resident Tregs act to abolish antitumor T cell immunity through enhanced peripheral tolerance to or “immunological ignorance” of the tumor itself. The gene discussed is CD274; the disease is neoplasm.