miR-142-5p expression is downregulated in CD4+ T cells from patients with the multisystem autoimmune disease systemic lupus erythematosus (SLE) compared with healthy controls and overexpressed in an animal model of multiple sclerosis, suggesting that miR-142 plays a role in autoimmune disease (19, 20). The gene discussed is CD4; the disease is systemic lupus erythematosus.