HIF1A and neoplasm: A Recent study has shown that, when exposed to hypoxic microenvironment, breast cancer cells increased their CD47 expression and in favor of a CSC‐like phenotype, which mediated by a direct binding of HIF‐1α to the CD47 promoter.[33] The Data from Shigemasa S et.al shows that CD47 is regulated by miR‐133a which probably function as a tumor suppressor.7 Our study provides preliminary proof that CD47 blockade may improve CSC eradicating strategy, while whether other novel and effective mechanisms exist merits further investigation.