A Recent study has shown that, when exposed to hypoxic microenvironment, breast cancer cells increased their CD47 expression and in favor of a CSC‐like phenotype, which mediated by a direct binding of HIF‐1α to the CD47 promoter.[33] The Data from Shigemasa S et.al shows that CD47 is regulated by miR‐133a which probably function as a tumor suppressor.7 Our study provides preliminary proof that CD47 blockade may improve CSC eradicating strategy, while whether other novel and effective mechanisms exist merits further investigation. The gene discussed is HIF1A; the disease is breast cancer.