When mean FAU in the skeletal muscles, body fat percentage, insulin sensitivity (M‐value in the hyperinsulinemic euglycemic clamp) and VO2peak were added as factors into the model, the overall training effect (time) was no longer significant (P = 0.10) and the difference between subject groups (healthy or T2D/prediabetes) disappeared (P = 0.16). The gene discussed is INS; the disease is prediabetes syndrome.