Studies have shown that the growth, migration, and invasion of cancer cells are associated with high expression of COX‐2.32, 38, 39, 40 To investigate whether IATL affects the COX‐2 signaling pathway in GBM, Western blotting and RT‐PCR were performed to analyze the protein and gene expression of COX‐2. This evidence concerns the gene PTGS2 and glioblastoma.