MMP9 and central nervous system cancer: MMP‐2 and MMP‐9 could play an important role in disrupting the extracellular matrix; furthermore, MMP‐2 and MMP‐9 are negatively correlated with the prognosis of glioma patients.56, 57 Our research also confirmed that IATL significantly reduced the expression of MMP‐2 and MMP‐9 and inhibited the migration and invasion of GBM cells.