The overexpression of COX‐2 promotes cell proliferation and increases tumor invasion and migration; thus, COX‐2 plays an important role in tumor development and progression.44 In turn, the targeted inhibition of COX‐2 is a potential therapeutic strategy, and finding additional targeted anticancer drugs is important.45, 46, 47, 48 Because CB is a classic anti‐inflammatory agent, we used CB as a positive inhibitor of COX‐2 expression. The gene discussed is PTGS2; the disease is neoplasm.