POU5F1 and skin neoplasm: Firstly, recent reports showed that some of pluripotent genes could promote the self‐renewal of CSCs which maintain the stemness of ESCs and iPSCs such as Oct4 and Nanog. 36, 37 Our findings and others indicate that CSCs may utilize the self‐renewal pathways of the NSCs.38 Secondly, a study in the skin tumor model showed that only the skin stem cells, not the progenitor cells could give arise to skin CSCs to initiate tumor formation.39 This study argues that the source of CSCs, in rapidly regenerating skin, is likely the normal skin stem cells.