And lastly, there is another school of thinking regarding the source of CSCs in human cancer as tumor cells that have the plasticity similar to somatic iPS.40 Since Nanog is a key regulator for the maintenance of stemness of NSCs as well for inducing the iPS state, our results can not differentiate the function of Nr5a2 via Nanog on LLC‐SD whether through regulating the stemness of original stem cells enriched in LLC‐SD, or through regulating the plasticity of parental LLC cells to give arise to LLC‐SD. This evidence concerns the gene NANOG and neoplasm.