The effects of Nr5a2 in promoting LLC‐SD oncogenesis and metastatic progression, as well as the resultant shorter survival (Figures 3, 4 and Table 1) are consistent with but add new perspectives to the previously reported oncogenic activity of Nr5a2 in NSCLC.32 This set of in vivo observations, made in the orthotopic and syngeneic model of lung cancer, have overcome the lack of proper animal models in CSC research for the evaluation of CSC cancer biology properties in vivo. The gene discussed is NR5A2; the disease is non-small cell lung carcinoma.