The effect on Aβ phagocytosis was not replicated by other studies with TREM2−/+‐ and TREM2 KO‐AD mice (Song et al., 2018; Ulrich et al., 2014) and TREM2 KO non‐AD mice (Zhao et al., 2018), reflecting the previously observed inconsistencies in plaque numbers between mouse models. This evidence concerns the gene TREM2 and Alzheimer disease.