MAPT and Alzheimer disease: The most widely accepted explanation for AD, known as the “amyloid hypothesis,” proposes that misfolding and aggregation of the peptide β‐amyloid (Aβ) causes a linear cascade of pathology that results in both extracellular amyloid plaques and intracellular deposition of misfolded Tau protein that forms neurofibrillary tangles (Chen et al., 2017; C. C. Tan, Zhang, Tan, & Yu, 2018).