The morphology of the plaques, rather than the number, appears to be more indicative of the TREM2 genotype: TREM2 KO‐AD mice present diffused amyloid plaques, with amyloid filaments extending outwards, and fewer compact amyloid plaques than AD mice (Jay, Hirsch, et al., 2017; Wang et al., 2016). Here, TREM2 is linked to amyloidosis.