Comparisons with the Yap1 knockout model however remain difficult, because only one marker at one time point has been assessed in the latter.11 Anyhow, our approach of acute deficiency induced prior to hepatectomy demonstrates that YAP1’s specific contribution is vital for early but dispensable for later stages of liver regeneration, a finding corroborated with our liver failure model. This evidence concerns the gene YAP1 and Hepatic failure.