Liver failure after eHx develops due to deficient progression through the hepatocellular S‐ and M‐phases associated with a shutdown of pro‐proliferative pathways.2, 3, 16 If YAP1 indeed functions in the early cell cycle (including the S‐phase) but is dispensable for the M‐phase, its activity should be impaired at 32 hours, but not 48 hours, after eHx. This evidence concerns the gene YAP1 and liver failure.