A genome-wide analysis study (GWAS) reported by Chartier-Harlin revealed the presence of eIF4G1 missense mutations p.Ala502Val (A502V) and p.Arg1205His (R1205H) in a French family and seven other PD-afflicted families from different countries but was absent in 4050 healthy controls [75]. Here, EIF4G1 is linked to Parkinson disease.