The PD-linked mutant LRRK2, such as G2019S LRRK2 mutant with increased LRRK2 kinase activity, can induce hyperphosphorylation of 4E-BP1 and deregulated protein translation, which can be relevant to LRRK2 mutation-induced DA neuron degeneration in PD [106]. The gene discussed is LRRK2; the disease is Parkinson disease.